3-m-tolylprop-2-yne-1,1-diyl diacetate

Base Information

• Chemical Name: 3-m-tolylprop-2-yne-1,1-diyl diacetate
• CAS No.: 1260421-80-4
• Molecular Formula: C₁₄H₁₄O₄
• Molecular Weight: 246.263
• Mol file: 1260421-80-4.mol

Synonyms:3-m-tolylprop-2-yne-1,1-diyl diacetate

Chemical Property of 3-m-tolylprop-2-yne-1,1-diyl diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-m-tolylprop-2-yne-1,1-diyl diacetate

There total 1 articles about 3-m-tolylprop-2-yne-1,1-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

acetic anhydride (108-24-7) + 3-(3-methylphenyl)prop-2-ynal (62358-91-2) → 3-m-tolylprop-2-yne-1,1-diyl diacetate (1260421-80-4)

Guidance literature:

With iron(III) chloride; In dichloromethane; at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1016/j.tetlet.2010.10.013

Reference yield: 46.0%

3-m-tolylprop-2-yne-1,1-diyl diacetate (1260421-80-4) + ethylmagnesium bromide (925-90-6) → 3-m-tolylpenta-1,2-dienyl acetate (1260422-05-6)

Guidance literature:

ethylmagnesium bromide; With copper(l) iodide; lithium bromide; In tetrahydrofuran; tert-butyl methyl ether; at -10 ℃; Inert atmosphere;

3-m-tolylprop-2-yne-1,1-diyl diacetate; In tetrahydrofuran; tert-butyl methyl ether; at -10 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.013

upstream raw materials:

acetic anhydride

3-(3-methylphenyl)prop-2-ynal

Downstream raw materials:

3-m-tolylpenta-1,2-dienyl acetate

Refernces