2,3-DIHYDRO-1H-INDOLE-4-CARBONITRILE HYDROCHLORIDE

Base Information

• Chemical Name: 2,3-DIHYDRO-1H-INDOLE-4-CARBONITRILE HYDROCHLORIDE
• CAS No.: 885278-80-8
• Molecular Formula: C9H8 N2
• Molecular Weight: 144.176
• Hs Code.: 2933990090
• Mol file: 885278-80-8.mol

Synonyms:2,3-Dihydro-1H-indole-4-carbonitrile

Chemical Property of 2,3-DIHYDRO-1H-INDOLE-4-CARBONITRILE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 304.5±31.0 °C(Predicted)
• PKA: 3.80±0.20(Predicted)
• PSA: 35.82000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 1.66428
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydro-1H-indole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DIHYDRO-1H-INDOLE-4-CARBONITRILE HYDROCHLORIDE

There total 8 articles about 2,3-DIHYDRO-1H-INDOLE-4-CARBONITRILE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-cyanoindole (16136-52-0) → indoline-4-carbonitrile (885278-80-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 50 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113459

Reference yield: 70.0%

→ indoline-4-carbonitrile (885278-80-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 0 - 20 ℃; for 2h;

Reference yield: 66.0%

C11H7F3N2O (1578263-85-0) → indoline-4-carbonitrile (885278-80-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jm401625b

upstream raw materials:

zinc(II) cyanide

4-bromo-2,3-dihydro-1H-indole

4-bromo-1H-indole

C₁₀H₇BrF₃NO

Downstream raw materials:

C₁₉H₁₈N₂O₃

1-(3-(4-fluorophenoxy)-2(S)-hydroxy-2-methylpropanoyl)indoline-4-carbonitrile

C₁₉H₁₇FN₂O₃

C₁₉H₁₇FN₂O₃

Refernces

• 1、 Dong, Yanan,Li, Yuehui,Yang, Peiju,Zhao, Shizhen. "Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos–Ni(I) species". . . Retrieved 2020/08/19.
• 2、 Chekler, Eugene L. Piatnitski,Unwalla, Rayomond,Khan, Taukeer A.,Tangirala, Raghuram S.,Johnson, Mark,St. Andre, Michael,Anderson, James T.,Kenney, Thomas,Chiparri, Sue,McNally, Chris,Kilbourne, Edward,Thompson, Catherine,Nagpal, Sunil,Weber, Gregory,Schelling, Scott,Owens, Jane,Morris, Carl A.,Powell, Dennis,Verhoest, Patrick R.,Gilbert, Adam M.. "1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators". . p. 2462 - 2471. Retrieved 2014/04/17.