2-4-chlorophenylethylcarbamic acid methyl ester

Base Information

• Chemical Name: 2-4-chlorophenylethylcarbamic acid methyl ester
• CAS No.: 328281-40-9
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.664
• Mol file: 328281-40-9.mol

Synonyms:2-4-chlorophenylethylcarbamic acid methyl ester

Chemical Property of 2-4-chlorophenylethylcarbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-4-chlorophenylethylcarbamic acid methyl ester

There total 3 articles about 2-4-chlorophenylethylcarbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chlorophenylethylamine (156-41-2) + methyl chloroformate (79-22-1) → 2-4-chlorophenylethylcarbamic acid methyl ester (328281-40-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.0c01441

Reference yield: 87.0%

methyl tert-butyl(4-chlorophenethyl)carbamate → 2-4-chlorophenylethylcarbamic acid methyl ester (328281-40-9)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 15h;

DOI:10.1021/acs.joc.8b01538

Reference yield:

N-tert-butyl-[2-(4'-chloro)phenyl]ethylamine (748133-57-5) → 2-4-chlorophenylethylcarbamic acid methyl ester (328281-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate / acetonitrile / 16 h / 20 °C / Schlenk technique; Sealed tube; Irradiation

2: trifluoroacetic acid / 15 h / 20 °C

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; trifluoroacetic acid; In acetonitrile;

DOI:10.1021/acs.joc.8b01538

upstream raw materials:

4-chlorophenylethylamine

methyl chloroformate

N-tert-butyl-[2-(4'-chloro)phenyl]ethylamine

Downstream raw materials:

7-chloro-1,2,3,4-tetrahydroisoquinolin-1-one

4-chlorophenylethylamine

methyl (2-p-chlorophenylethyl)carbamic acid methyl ester

2-(4-chlorophenyl)ethanamine hydrochloride

Refernces

• 1、 -. "INHIBITORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D (NAPE-PLD)". . . Retrieved 2019/12/15.
• 2、 Faderl, Christian,Budde, Simon,Kachkovskyi, Georgiy,Rackl, Daniel,Reiser, Oliver. "Visible Light-Mediated Decarboxylation Rearrangement Cascade of Aryl- N-(acyloxy)phthalimides". . p. 12192 - 12206. Retrieved 2018/09/21.