MORPHOLINE-3-ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: MORPHOLINE-3-ACETIC ACID METHYL ESTER
• CAS No.: 885273-89-2
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Hs Code.: 2934999090
• Mol file: 885273-89-2.mol

Synonyms:Morpholine-3-acetic acid methyl ester;3-Morpholineacetic acid, methyl ester;Morpholine-3-acetic acid methyl ester hydrochloride;MORPHOLINE-3-ACETIC ACID METHYL ESTER HCL

Chemical Property of MORPHOLINE-3-ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0838mmHg at 25°C
• Refractive Index: 1.431
• Boiling Point: 226°C at 760 mmHg
• PKA: 7.78±0.40(Predicted)
• Flash Point: 90.5°C
• PSA: 47.56000
• Density: 1.053g/cm³
• LogP: -0.13330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

methyl2-(morpholin-3-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MORPHOLINE-3-ACETIC ACID METHYL ESTER

There total 2 articles about MORPHOLINE-3-ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-methyl 2-(morpholin-3-ylidene)acetate → 2-(morpholin-3-yl)ethanoic acid methyl ester (1217976-31-2,885273-89-2)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In 1,4-dioxane; at 20 ℃; for 0.333333h;

Reference yield:

2,2-dimethyl-5-(morpholin-3-ylidene)-1,3-dioxane-4,6-dione → 2-(morpholin-3-yl)ethanoic acid methyl ester (1217976-31-2,885273-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / Reflux

2: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 0.33 h / 20 °C

With sodium tetrahydroborate; acetic acid; In 1,4-dioxane; methanol;

Reference yield:

2-(morpholin-3-yl)ethanoic acid methyl ester (1217976-31-2,885273-89-2) → 2-(4-((benzyloxy)carbonyl)morpholin-3-yl)acetic acid (885273-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 1 h / 20 °C

2: lithium hydroxide monohydrate / methanol; water / 2 h / 20 - 50 °C

With lithium hydroxide monohydrate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;

Downstream raw materials:

2-(4-((benzyloxy)carbonyl)morpholin-3-yl)acetic acid

Refernces