α-acetamido-N-benzyl-α-thiocarbamoylacetamide

Base Information

• Chemical Name: α-acetamido-N-benzyl-α-thiocarbamoylacetamide
• CAS No.: 147495-36-1
• Molecular Formula: C₁₂H₁₅N₃O₂S
• Molecular Weight: 265.336
• Mol file: 147495-36-1.mol

Synonyms:α-acetamido-N-benzyl-α-thiocarbamoylacetamide

Chemical Property of α-acetamido-N-benzyl-α-thiocarbamoylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of α-acetamido-N-benzyl-α-thiocarbamoylacetamide

There total 3 articles about α-acetamido-N-benzyl-α-thiocarbamoylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

α-acetamido-N-benzyl-α-cyanoacetamide (58685-35-1) → α-acetamido-N-benzyl-α-thiocarbamoylacetamide (147495-36-1)

Guidance literature:

With O,O-Diethyl hydrogen phosphorodithioate; In methanol; ethanol; water; at 70 ℃; for 6h;

DOI:10.1021/jm00074a016

Reference yield:

benzylamine (100-46-9) → α-acetamido-N-benzyl-α-thiocarbamoylacetamide (147495-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / ethanol / 18 h / Ambient temperature

2: 44 percent / O,O'-diethyl dithiophosphonate, / methanol; ethanol; H₂O / 6 h / 70 °C

With O,O-Diethyl hydrogen phosphorodithioate; In methanol; ethanol; water;

DOI:10.1021/jm00074a016

Reference yield:

ethyl 2-acetamido-2-cyanoacetate (90877-70-6,4977-62-2) → α-acetamido-N-benzyl-α-thiocarbamoylacetamide (147495-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / ethanol / 18 h / Ambient temperature

2: 44 percent / O,O'-diethyl dithiophosphonate, / methanol; ethanol; H₂O / 6 h / 70 °C

With O,O-Diethyl hydrogen phosphorodithioate; In methanol; ethanol; water;

DOI:10.1021/jm00074a016

upstream raw materials:

α-acetamido-N-benzyl-α-cyanoacetamide

benzylamine

ethyl 2-acetamido-2-cyanoacetate

Refernces