5,4'-dichloro-2-methylaminobenzophenone

Base Information

• Chemical Name: 5,4'-dichloro-2-methylaminobenzophenone
• CAS No.: 78961-59-8
• Molecular Formula: C₁₄H₁₁Cl₂NO
• Molecular Weight: 280.153
• Mol file: 78961-59-8.mol

Synonyms:5,4'-dichloro-2-methylaminobenzophenone

Chemical Property of 5,4'-dichloro-2-methylaminobenzophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,4'-dichloro-2-methylaminobenzophenone

There total 5 articles about 5,4'-dichloro-2-methylaminobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-4'-chloro-5-chlorobenzophenone (837-58-1,136266-81-4) + dimethyl sulfate (77-78-1) → 5,4'-dichloro-2-methylaminobenzophenone (78961-59-8)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; at 60 ℃; for 2h;

DOI:10.1055/s-1981-29477

Reference yield: 85.0%

CH3O4S(1-)*C14H10Cl2NO(1+) (1206893-20-0) → 5,4'-dichloro-2-methylaminobenzophenone (78961-59-8)

Guidance literature:

With Saccharomyces cerevisiae bakers' yeast; In methanol; at 20 ℃; for 7.5h; pH=7; aq. phosphate buffer; Microbiological reaction; shaking;

DOI:10.1007/s00706-009-0159-x

Reference yield:

4-chlorobenzonitrile (100-00-5) → 5,4'-dichloro-2-methylaminobenzophenone (78961-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / KOH / methanol; benzene / 3 h / Ambient temperature

2: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux

With hydrogenchloride; potassium hydroxide; iron; In methanol; benzene;

DOI:10.1135/cccc19851064

upstream raw materials:

3-(4-chlorobenzene)-5-chloro-2,1-benzoisoxazole

dimethyl sulfate

2-amino-4'-chloro-5-chlorobenzophenone

4-chlorobenzonitrile

Downstream raw materials:

4-chlorodiazepam

N-<4-chloro-2-(4-chlorobenzoyl)phenyl>-N-methylchloroacetamide

N-<4-chloro-2-(4-chlorobenzoyl)phenyl>-N-methylphthalimidoacetate

Refernces

• 1、 Vejdelek,Polivka,Protiva. "Synthesis of 7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-1,4-benzodiazepin-2-one". . p. 1064 - 1069. Retrieved 2007/10/02.