2-chloro-5-methylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-chloro-5-methylphenyl trifluoromethanesulfonate
• CAS No.: 1131890-85-1
• Molecular Formula: C₈H₆ClF₃O₃S
• Molecular Weight: 274.648
• Mol file: 1131890-85-1.mol

Synonyms:2-chloro-5-methylphenyl trifluoromethanesulfonate

Chemical Property of 2-chloro-5-methylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-chloro-5-methylphenyl trifluoromethanesulfonate

There total 2 articles about 2-chloro-5-methylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-chloro-5-methylanisole (73909-16-7) → 2-chloro-5-methylphenyl trifluoromethanesulfonate (1131890-85-1)

Guidance literature:

With pyridine; at 0 - 20 ℃; Cooling with ice;

DOI:10.1021/jm201061j

Reference yield: 90.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-chloro-5-methylphenol (615-74-7) → 2-chloro-5-methylphenyl trifluoromethanesulfonate (1131890-85-1)

Guidance literature:

With diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 78.0%

phenyl(1-phenylethylidene)amine (1749-19-5) + 2-chloro-5-methylphenyl trifluoromethanesulfonate (1131890-85-1) → 5-methyl-1,2-diphenyl-1H-indole (1131890-87-3)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; lithium tert-butoxide; XPhos; In 1,4-dioxane; at 110 ℃; for 14h; regioselective reaction; Inert atmosphere;

upstream raw materials:

trifluoromethylsulfonic anhydride

2-chloro-5-methylphenol

2-chloro-5-methylanisole

Downstream raw materials:

5-methyl-1,2-diphenyl-1H-indole

2,5-dimethyl-1-phenyl-1H-indole

1-tert-butyl-5-methyl-2-phenyl-1H-indole

2-(2-chloro-5-methylphenyl)-1,2-propene

Refernces

• 1、 Barluenga, Jose,Jimenez-Aquino, Agustin,Aznar, Fernando,Valdes, Carlos. "Modular synthesis of indoles from imines and o-dihaloarenes or o-chlorosulfonates by a Pd-catalyzed cascade process". supporting information; experimental part. p. 4031 - 4041. Retrieved 2009/09/04.