4,4'-difluoro-benzilic acid ethyl ester

Base Information

• Chemical Name: 4,4'-difluoro-benzilic acid ethyl ester
• CAS No.: 379-59-9
• Molecular Formula: C₁₆H₁₄F₂O₃
• Molecular Weight: 292.282
• Mol file: 379-59-9.mol

Synonyms:4,4'-difluoro-benzilic acid ethyl ester

Chemical Property of 4,4'-difluoro-benzilic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-difluoro-benzilic acid ethyl ester

There total 5 articles about 4,4'-difluoro-benzilic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethanol (64-17-5) + 4,4'-difluoro-benzilic acid (357-60-8) → 4,4'-difluoro-benzilic acid ethyl ester (379-59-9)

Guidance literature:

With thionyl chloride; at 0 ℃; for 4h; Heating / reflux;

Reference yield:

1,2-bis(4-fluorophenyl)ethane-1,2-dione (579-39-5) → 4,4'-difluoro-benzilic acid ethyl ester (379-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic KOH

2: Ag₂O

With potassium hydroxide; silver(l) oxide;

DOI:10.1002/hlca.19550380108

Reference yield:

α,α,α',α'-tetrachloro-4,4'-difluoro-bibenzyl (565-04-8) → 4,4'-difluoro-benzilic acid ethyl ester (379-59-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous acetic acid / 160 °C

2: aq.-ethanolic KOH

3: Ag₂O

With potassium hydroxide; acetic acid; silver(l) oxide;

DOI:10.1002/hlca.19550380108

upstream raw materials:

4,4'-difluoro-benzilic acid

ethyl iodide

1,2-bis(4-fluorophenyl)ethane-1,2-dione

α,α,α',α'-tetrachloro-4,4'-difluoro-bibenzyl

Downstream raw materials:

2, 2-bis-(4-fluorophenyl)-2-propoxy acetic acid ethyl ester

Refernces