2-CHLORO-5-FLUORO-4-IODOPYRIDINE

Base Information

• Chemical Name: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE
• CAS No.: 884494-49-9
• Molecular Formula: C5H2ClFIN
• Molecular Weight: 257.433
• Hs Code.: 2933399090
• Mol file: 884494-49-9.mol

Synonyms:2-CHLORO-5-FLUORO-4-IODOPYRIDINE

Chemical Property of 2-CHLORO-5-FLUORO-4-IODOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.614
• Boiling Point: 242.223 °C at 760 mmHg
• PKA: -2.37±0.10(Predicted)
• Flash Point: 100.293 °C
• PSA: 12.89000
• Density: 2.129 g/cm³
• LogP: 2.47870
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-fluoro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-FLUORO-4-IODOPYRIDINE

There total 1 articles about 2-CHLORO-5-FLUORO-4-IODOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-chloro-5-fluoropyridine (31301-51-6) → 2-chloro-5-fluoro-4-iodopyridine (884494-49-9)

Guidance literature:

2-chloro-5-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; for 1h;

Reference yield: 95.0%

2-chloro-5-fluoro-4-iodopyridine (884494-49-9) + 4-fluoro-2-methoxyphenylboronic acid (179899-07-1) → 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridine (1602486-03-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01000

Reference yield: 87.0%

2-chloro-5-fluoro-4-iodopyridine (884494-49-9) + phenylboronic acid (98-80-6) → 2-chloro-5-fluoro-4-phenylpyridine

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 16.67h; Inert atmosphere; Microwave irradiation; Sealed tube;

upstream raw materials:

2-chloro-5-fluoropyridine

Downstream raw materials:

2-chloro-5-fluoroisonicotinonitrile

2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide

5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine

5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfanyl)methyl]pyridin-2-yl}pyridin-2-amine

Refernces

• 1、 -. "PYRIDYL SUBSTITUTED INDOLE COMPOUNDS". Page/Page column 168. . Retrieved 2018/03/28.
• 2、 -. "THERAPEUTIC INHIBITORY COMPOUNDS". Paragraph 00200. . Retrieved 2017/01/23.