N-benzyl-2-bromo-4-methoxybenzeneamine

Base Information

• Chemical Name: N-benzyl-2-bromo-4-methoxybenzeneamine
• CAS No.: 162712-04-1
• Molecular Formula: C₁₄H₁₄BrNO
• Molecular Weight: 292.175
• Mol file: 162712-04-1.mol

Synonyms:N-benzyl-2-bromo-4-methoxybenzeneamine

Chemical Property of N-benzyl-2-bromo-4-methoxybenzeneamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-benzyl-2-bromo-4-methoxybenzeneamine

There total 4 articles about N-benzyl-2-bromo-4-methoxybenzeneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl bromide (100-39-0) + 4-methoxy-aniline (104-94-9) → N-benzyl-2-bromo-4-methoxybenzeneamine (162712-04-1)

Guidance literature:

benzyl bromide; 4-methoxy-aniline; With sodium hydrogencarbonate; In water;

With bromine; acetic acid; at 10 - 15 ℃;

DOI:10.1016/j.ejphar.2017.09.024

Reference yield: 90.0%

benzyl(4-methoxyphenyl)amine (17377-95-6) → N-benzyl-2-bromo-4-methoxybenzeneamine (162712-04-1)

Guidance literature:

With bromine; acetic acid; at 10 - 15 ℃; for 2h;

DOI:10.1002/jhet.5570320101

Reference yield: 62.0%

2-bromo-4-methoxyaniline (32338-02-6) + benzaldehyde (100-52-7) → N-benzyl-2-bromo-4-methoxybenzeneamine (162712-04-1)

Guidance literature:

2-bromo-4-methoxyaniline; benzaldehyde; In methanol; at 20 ℃; for 6h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/jo702290f

upstream raw materials:

benzyl(4-methoxyphenyl)amine

2-bromo-4-methoxyaniline

benzaldehyde

benzyl bromide

Downstream raw materials:

1-benzyl-1-(2-bromo-4-methoxyphenyl)urea

C₂₇H₂₇BrN₂O₄

benzyl[4-methoxy-2-(propen-1-yl)phenyl]amine

Refernces

• 1、 Hogan, Anne-Marie L.,O'Shea, Donal F.. "Asymmetric cascade reaction sequences via chiral lithiated intermediates". . p. 2503 - 2509. Retrieved 2008/09/19.
• 2、 Lee,Huang,Lin,Shih,Lee,Lin. "Synthesis of 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives as possible nonsteroidal cardiotonics". . p. 1 - 11. Retrieved 2007/10/02.