ethyl 2,4,6-trifluorobenzoate

Base Information

• Chemical Name: ethyl 2,4,6-trifluorobenzoate
• CAS No.: 773134-91-1
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.149
• Hs Code.: 9999999999
• Mol file: 773134-91-1.mol

Synonyms:ethyl 2,4,6-trifluorobenzoate

Chemical Property of ethyl 2,4,6-trifluorobenzoate

Chemical Property:

• Vapor Pressure: 0.116mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

2,4,6-Trifluorobenzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,4,6-trifluorobenzoate

There total 3 articles about ethyl 2,4,6-trifluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 2,4,6-trifluorobenzoyl chloride (79538-29-7) → ethyl 2,4,6-trifluorobenzoate (773134-91-1)

Guidance literature:

With triethylamine; Yield given;

DOI:10.1021/jm9603532

Reference yield:

ethanol (64-17-5) + 2,4,6-trifluorobenzoic acid (28314-80-9) → ethyl 2,4,6-trifluorobenzoate (773134-91-1)

Guidance literature:

With sulfuric acid; at 80 ℃; for 12h;

Reference yield:

2,4,6-trifluorobenzoic acid (28314-80-9) → ethyl 2,4,6-trifluorobenzoate (773134-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 0.5 h / 80 °C

2: Et₃N

With thionyl chloride; triethylamine;

DOI:10.1021/jm9603532

upstream raw materials:

ethanol

2,4,6-trifluorobenzoyl chloride

2,4,6-trifluorobenzoic acid

Downstream raw materials:

ethyl 3-nitro-2,4,6-trifluorobenzoate

4-[(4-Bromo-3-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-2,6-difluoro-benzoic acid ethyl ester

ethyl 2,6-difluoro-4-aminobenzoate

4-Azido-2,6-difluoro-benzoic acid ethyl ester

Refernces

• 1、 -. "BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS". Page/Page column 163. . Retrieved 2017/02/09.
• 2、 Teng,Duong,Klein,Pino,Chandraratna. "Identification of a retinoic acid receptor α subtype specific agonist". . p. 3035 - 3038. Retrieved 2007/10/03.