(R)-3-N-CBZ-AMINOPYRROLIDINE

Base Information

• Chemical Name: (R)-3-N-CBZ-AMINOPYRROLIDINE
• CAS No.: 879275-77-1
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Mol file: 879275-77-1.mol

Synonyms:Carbamicacid, (3R)-3-pyrrolidinyl-, phenylmethyl ester (9CI);

Chemical Property of (R)-3-N-CBZ-AMINOPYRROLIDINE

Chemical Property:

• Vapor Pressure: 4.69E-06mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 382.5 °C at 760 mmHg
• Flash Point: 185.1 °C
• PSA: 50.36000
• Density: 1.16 g/cm³
• LogP: 1.99440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-3-N-Cbz-aminopyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-N-CBZ-AMINOPYRROLIDINE

There total 3 articles about (R)-3-N-CBZ-AMINOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-(benzyloxycarbonylamino)-N-hydroxy-pyrrolidine → (R)-benzyl pyrrolidin-3-ylcarbamate (879275-77-1)

Guidance literature:

With hydrogen; nickel; In ethanol; for 4 - 6h; under 750.075 - 2625.26 Torr;

Reference yield:

(R)-pyrrolidin-3-yl-carbamic acid benzyl ester hydrochloride (884653-79-6) → (R)-benzyl pyrrolidin-3-ylcarbamate (879275-77-1)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

benzyl (R)-pyrrolidin-3-ylcarbamate hydrochloride → (R)-benzyl pyrrolidin-3-ylcarbamate (879275-77-1)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane;

upstream raw materials:

(R)-pyrrolidin-3-yl-carbamic acid benzyl ester hydrochloride

Downstream raw materials:

{(R)-1-[9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-carbamic acid benzyl ester

{(R)-1-[9-((3aS,4R,6S,6aR)-2,2-dimethyl-6-propionylamino-tetrahydro-cyclopental[1,3]dioxol-4-yl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-carbamic acid benzyl ester

benzyl (R)-1-(2-(2-fluoro-6-hydroxyphenyl)-7-methyl-quinazolin-4-yl)pyrrolidin-3-ylcarbamate

(R)-tert-butyl 3-(benzyloxycarbonylamino)pyrrolidine-1-carboxylate

Refernces

• 1、 -. "ORGANIC COMPOUNDS". Page/Page column 50. . Retrieved 2008/06/13.
• 2、 -. "Process for the manufacture of 3-amino-pyrrolidine derivatives". Page 4. . Retrieved 2008/06/13.