Technology Process of (2R*S*,,3R*,4R*)-4-hydroxy-2,3-dimethylcyclohexanone
There total 9 articles about (2R*S*,,3R*,4R*)-4-hydroxy-2,3-dimethylcyclohexanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
for 1h;
Heating;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / H2 / Raney nickel (W-7) / methanol / 4 h / 130 °C / 95616.1 Torr
2: 8N Jones chromic acid reagent / acetone / 1 h / Ambient temperature
3: p-toluenesulfonic acid monohydrate / benzene / 20 h / Heating; azeotropic removal of water
4: p-toluenesulfonic acid monohydrate, H2O / acetone / 2 h / Heating
5: 86 percent / Na, isopropyl alcohol / toluene / 1 h / Heating
6: 85 percent / 0.5N HCl / tetrahydrofuran / 1 h / Heating
With
hydrogenchloride; water; hydrogen; sodium; chromic acid; toluene-4-sulfonic acid; isopropyl alcohol;
Raney nickel (W-7);
In
tetrahydrofuran; methanol; acetone; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / TosOH
2: 68 percent
4: 85 percent / 0.5N HCl / tetrahydrofuran / 1 h / Heating
With
hydrogenchloride; toluene-4-sulfonic acid;
In
tetrahydrofuran;
