2,4-bis(benzyloxy)-6-pentylbenzoic acid

Base Information

• Chemical Name: 2,4-bis(benzyloxy)-6-pentylbenzoic acid
• CAS No.: 104307-50-8
• Molecular Formula: C₂₆H₂₈O₄
• Molecular Weight: 404.506
• Mol file: 104307-50-8.mol

Synonyms:2,4-bis(benzyloxy)-6-pentylbenzoic acid

Chemical Property of 2,4-bis(benzyloxy)-6-pentylbenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,4-bis(benzyloxy)-6-pentylbenzoic acid

There total 6 articles about 2,4-bis(benzyloxy)-6-pentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2,4-dibenzyloxy-6-pentylbenzoate (104307-49-5) → 2,4-bis(benzyloxy)-6-pentylbenzoic acid (104307-50-8)

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 90 ℃; for 24h;

Reference yield: 61.0%

2,4-bis(benzyloxy)-6-pentylbenzaldehyde → 2,4-bis(benzyloxy)-6-pentylbenzoic acid (104307-50-8)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; dimethyl sulfoxide; at 20 ℃; for 14h;

DOI:10.1039/c3md00238a

Reference yield:

Olivetol (500-66-3) → 2,4-bis(benzyloxy)-6-pentylbenzoic acid (104307-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 18 h / 0 - 20 °C

2: potassium carbonate / acetone / 12 h / Reflux

3: sodium dihydrogenphosphate; sodium chlorite / dimethyl sulfoxide; water / 14 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; potassium carbonate; trichlorophosphate; In water; dimethyl sulfoxide; acetone; 1: |Vilsmeier-Haack Formylation;

DOI:10.1039/c3md00238a

upstream raw materials:

ethyl 2,4-dibenzyloxy-6-pentylbenzoate

2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester

benzyl bromide

Olivetol

Downstream raw materials:

benzyl 2,4-di-O-benzylimbricarate

benzyl 4,6-bis(benzyloxy)-3-formyl-2-pentylbenzoate

anziaic acid

2,4-dihydroxyl-6-pentylbenzoic acid

Refernces

• 1、 -. "CANNABINOID DERIVATIVES". Paragraph 0138. . Retrieved 2021/01/23.
• 2、 Elix, John A.,Parker, John L.,Tearne, Philip D.,Wardlaw, Judith H.. "Synthesis of Further Divarinol and Olivetol Lichen para-Depsides". . p. 1863 - 1871. Retrieved 2007/10/02.