4-picolyl 4'-hydroxy-3'-nitrophenylacetate

Base Information

• Chemical Name: 4-picolyl 4'-hydroxy-3'-nitrophenylacetate
• CAS No.: 80633-28-9
• Molecular Formula: C₁₄H₁₂N₂O₅
• Molecular Weight: 288.26
• Mol file: 80633-28-9.mol

Synonyms:4-picolyl 4'-hydroxy-3'-nitrophenylacetate

Chemical Property of 4-picolyl 4'-hydroxy-3'-nitrophenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-picolyl 4'-hydroxy-3'-nitrophenylacetate

There total 1 articles about 4-picolyl 4'-hydroxy-3'-nitrophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

pyridine-4-methanol (586-95-8) → 4-picolyl 4'-hydroxy-3'-nitrophenylacetate (80633-28-9)

Guidance literature:

With 1H-imidazole; In ethyl acetate; for 48h; Ambient temperature;

Reference yield: 94.0%

4-picolyl 4'-hydroxy-3'-nitrophenylacetate (80633-28-9) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → Z-Gly-ONp-Pic (80633-09-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Reference yield: 91.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + 4-picolyl 4'-hydroxy-3'-nitrophenylacetate (80633-28-9) → Boc-Phe-ONp-Pic (80645-36-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

upstream raw materials:

pyridine-4-methanol

Downstream raw materials:

Boc-Gly-ONp-Pic

Z-Leu-ONp-Pic

Boc-Phe-ONp-Pic

Z-Phe-ONp-Pic

Refernces