5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE

Base Information

• Chemical Name: 5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE
• CAS No.: 874959-68-9
• Molecular Formula: C5H3BrClNO2S
• Molecular Weight: 256.507
• Mol file: 874959-68-9.mol

Synonyms:5-Bromopyridin-2-sulfonylchloride;5-Bromopyridine-2-sulfonyl chloride;

Chemical Property of 5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.00194mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 301 °C at 760 mmHg
• PKA: -7.49±0.29(Predicted)
• Flash Point: 135.8 °C
• PSA: 55.41000
• Density: 1.893 g/cm³
• LogP: 2.85240
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Chloroform (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-pyridine-2-sulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of 5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE

There total 7 articles about 5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(benzylsulfanyl)-5-bromopyridine (874959-69-0) → 5-bromopyridine-2-sulfonyl chloride (874959-68-9)

Guidance literature:

With formic acid; chlorine; In dichloromethane; at 0 ℃; for 0.05h;

Reference yield: 94.0%

→ 5-bromopyridine-2-sulfonyl chloride (874959-68-9)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid; In water; acetonitrile; at 0 - 5 ℃; for 2h;

Reference yield: 71.0%

5-bromo-2-mercaptopyridine (56673-34-8) → 5-bromopyridine-2-sulfonyl chloride (874959-68-9)

Guidance literature:

With chlorine; In tetrachloromethane; water; at 0 ℃; for 0.333333h;

upstream raw materials:

2-(benzylsulfanyl)-5-bromopyridine

2,5-dibromopyridine

5-bromo-2-mercaptopyridine

2-iodo-5-bromopyridine

Downstream raw materials:

C₂₄H₂₂F₂N₄O₆S₃

5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-2-sulfonamide

5-bromopyridine-2-sulfonamide

Refernces

• 1、 -. "INHIBITOR COMPOUNDS". Page/Page column 63; 98-99. . Retrieved 2021/01/29.
• 2、 -. "5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS". Page/Page column 49; 50. . Retrieved 2020/09/19.