Technology Process of cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride
There total 5 articles about cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonia / isopropyl alcohol; water / 18 h / 75 - 85 °C / Sealed vessel; Industry scale
2.1: caesium carbonate / triphenylphosphine / N,N-dimethyl-formamide; water / 95 - 105 °C / Industry scale; Inert atmosphere
2.2: Industry scale; Inert atmosphere
3.1: hydrogenchloride / water
With
hydrogenchloride; ammonia; caesium carbonate;
triphenylphosphine;
In
water; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / -65 - -45 °C / Industry scale
1.2: 10 °C / Industry scale; Inert atmosphere
2.1: ammonia / isopropyl alcohol; water / 18 h / 75 - 85 °C / Sealed vessel; Industry scale
3.1: caesium carbonate / triphenylphosphine / N,N-dimethyl-formamide; water / 95 - 105 °C / Industry scale; Inert atmosphere
3.2: Industry scale; Inert atmosphere
4.1: hydrogenchloride / water
With
hydrogenchloride; ammonia; caesium carbonate;
triphenylphosphine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;
