3-methyl-5-phenyl-2-pentanone

Base Information

• Chemical Name: 3-methyl-5-phenyl-2-pentanone
• CAS No.: 5195-30-2
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.258
• Mol file: 5195-30-2.mol

Synonyms:3-methyl-5-phenyl-2-pentanone

Chemical Property of 3-methyl-5-phenyl-2-pentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-5-phenyl-2-pentanone

There total 18 articles about 3-methyl-5-phenyl-2-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-<1-chloro-1-(p-tolylsulfinyl)ethyl>-4-phenyl-2-butanol → 3-methyl-5-phenyl-2-pentanone (5195-30-2) + 4-methyl-1-phenylpentan-3-one (40463-09-0)

Guidance literature:

With tert.-butyl lithium; potassium hydride; In tetrahydrofuran; 1.) 0 deg C, 20 min; 2.) -70 deg C, 10 min;

DOI:10.1016/S0040-4020(01)89299-1

Reference yield: 20.0%

2-acetylpropanoic acid ethyl ester (609-14-3) + 1-phenyl-2-bromoethane (103-63-9) → 3-methyl-5-phenyl-2-pentanone (5195-30-2)

Guidance literature:

2-acetylpropanoic acid ethyl ester; 1-phenyl-2-bromoethane; With potassium carbonate; sodium iodide; In butanone; at 100 ℃; for 18h; Inert atmosphere;

With potassium hydroxide; In methanol; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.6b06847

Reference yield:

2,2-dimethyl-3-(2-phenylethyl)oxirane (40463-08-9) → 3-methyl-5-phenyl-2-pentanone (5195-30-2) + 4-methyl-1-phenylpentan-3-one (40463-09-0) + 4-Methyl-1-phenylpenta-1,3-diene (72486-22-7)

Guidance literature:

H-beta; In benzene; at 80 ℃; for 24h; Yield given; Yields of byproduct given;

DOI:10.1002/(sici)1099-0690(199904)1999:4<837::aid-ejoc837>3.0.co;2-7

upstream raw materials:

2-methyl-4-phenyl-butyryl chloride

cuprate de methyle

2-methyl-3-oxo-2-phenethyl-butyric acid ethyl ester

2,2-dimethyl-3-(2-phenylethyl)oxirane

Downstream raw materials:

3-methyl-5-phenyl-2-pentanol

2,3-Dimethyl-5-phenyl-2-pentanol

Refernces

• 1、 Akeboshi, Tomohiro,Ohtsuka, Yoshikazu,Ishihara, Takashi,Sugai, Takeshi. "Chemoenzymatic Approach toward the Pure Enantiomers of 2-Methyl-1,3-propanediol Mono(p-Methoxybenzyl Ether)". . p. 624 - 637. Retrieved 2007/10/03.
• 2、 Satoh, Tsuyoshi,Itoh, Norifumi,Gengyo, Kaoru,Takada, Sae,Asakawa, Naoyuki,et al.. "New Method for Generation of β-Oxido Carbenoid via Ligand Exchange Reaction of Sulfoxides: A Versatile Procedure for One-Carbon Homologation of Carbonyl Compounds". . p. 11839 - 11852. Retrieved 2007/10/02.