Technology Process of Hexadecanoic acid (R)-2-[benzyloxy-((1R,2R,3S,4R)-2,3,4-tris-benzyloxy-cyclohexyloxy)-phosphanyloxy]-1-hexadecanoyloxymethyl-ethyl ester
There total 9 articles about Hexadecanoic acid (R)-2-[benzyloxy-((1R,2R,3S,4R)-2,3,4-tris-benzyloxy-cyclohexyloxy)-phosphanyloxy]-1-hexadecanoyloxymethyl-ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 102 percent / diisopropylammonium tetrazolide / CH2Cl2 / 21 h / Ambient temperature
2: tetrazole / CH2Cl2; acetonitrile / 1.) room temperature, 16 h, 2.) 36 deg C, 69 h
With
1H-tetrazole; N,N-diisopropylamine tetrazolide;
In
dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(97)10003-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 88 percent / DMAP / pyridine / 1.) 0 deg C, 4.5 h, 2.) 4 deg C, 44 h
2: 86 percent / DMAP / CH2Cl2 / 139 h / Ambient temperature
3: 85 percent / Bu3SnH, AIBN / toluene / 8.83 h / Heating
4: 87 percent / aq. NaOH / tetrahydrofuran; methanol / 2.83 h / Ambient temperature
5: 102 percent / diisopropylammonium tetrazolide / CH2Cl2 / 21 h / Ambient temperature
6: tetrazole / CH2Cl2; acetonitrile / 1.) room temperature, 16 h, 2.) 36 deg C, 69 h
With
1H-tetrazole; dmap; sodium hydroxide; 2,2'-azobis(isobutyronitrile); N,N-diisopropylamine tetrazolide; tri-n-butyl-tin hydride;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(97)10003-5
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / conc. HCl / methanol / 48 h / Ambient temperature
2: 88 percent / DMAP / pyridine / 1.) 0 deg C, 4.5 h, 2.) 4 deg C, 44 h
3: 86 percent / DMAP / CH2Cl2 / 139 h / Ambient temperature
4: 85 percent / Bu3SnH, AIBN / toluene / 8.83 h / Heating
5: 87 percent / aq. NaOH / tetrahydrofuran; methanol / 2.83 h / Ambient temperature
6: 102 percent / diisopropylammonium tetrazolide / CH2Cl2 / 21 h / Ambient temperature
7: tetrazole / CH2Cl2; acetonitrile / 1.) room temperature, 16 h, 2.) 36 deg C, 69 h
With
1H-tetrazole; hydrogenchloride; dmap; sodium hydroxide; 2,2'-azobis(isobutyronitrile); N,N-diisopropylamine tetrazolide; tri-n-butyl-tin hydride;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(97)10003-5