19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol

Base Information

• Chemical Name: 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol
• CAS No.: 233768-84-8
• Molecular Formula: C₃₇H₅₀O₄Si
• Molecular Weight: 586.887
• Mol file: 233768-84-8.mol

Synonyms:19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol

Chemical Property of 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol

There total 3 articles about 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17-one (233768-83-7) → 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol (233768-84-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; for 6h; Ambient temperature;

DOI:10.1021/jm990064o

Reference yield:

19-hydroxy-4-androstene-3,17-dione (510-64-5) → 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol (233768-84-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

2: 45 percent / p-toluenesulfonic acid / 7.5 h / 83 °C

3: 84 percent / NaBH₄ / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jm990064o

Reference yield:

19-(tert-butyldiphenylsiloxy)-4-androstene-3,17-dione (233768-82-6) → 19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-ol (233768-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / p-toluenesulfonic acid / 7.5 h / 83 °C

2: 84 percent / NaBH₄ / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With sodium tetrahydroborate; toluene-4-sulfonic acid; In tetrahydrofuran; water;

DOI:10.1021/jm990064o

upstream raw materials:

19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17-one

19-hydroxy-4-androstene-3,17-dione

19-(tert-butyldiphenylsiloxy)-4-androstene-3,17-dione

Downstream raw materials:

19-(tert-butyldiphenylsiloxy)-3,3-(ethylenedioxy)-5-androsten-17β-yl acetate

Refernces