C₁₁H₈F₇NO

Base Information

• Chemical Name: C₁₁H₈F₇NO
• CAS No.: 947618-85-1
• Molecular Formula: C₁₁H₈F₇NO
• Molecular Weight: 303.179
• Mol file: 947618-85-1.mol

Synonyms:C₁₁H₈F₇NO

Chemical Property of C₁₁H₈F₇NO

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₁₁H₈F₇NO

There total 1 articles about C₁₁H₈F₇NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heptafluorobutyraldehyde ethyl hemiacetal (356-26-3) + 4-methoxy-aniline (104-94-9) → C11H8F7NO (947618-85-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 1.5h; Reflux; Inert atmosphere; Dean-Stark;

DOI:10.1021/acs.joc.8b01743

Reference yield: 80.0%

C11H8F7NO (947618-85-1) + methyl N-(4-chlorobenzylidene)glycinate (76862-09-4) → (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoropropyl)imidazolidine-4-carboxylate (1428259-76-0)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP; triethylamine; In diethyl ether; at -20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc43025a DOI:10.1039/c3cc43025a

Reference yield:

C11H8F7NO (947618-85-1) + methyl N-(4-chlorobenzylidene)glycinate (76862-09-4) → rac-(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoropropyl)imidazolidine-4-carboxylate

Guidance literature:

With silver(I) acetate; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc43025a DOI:10.1039/c3cc43025a

upstream raw materials:

heptafluorobutyraldehyde ethyl hemiacetal

4-methoxy-aniline

Downstream raw materials:

(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoropropyl)imidazolidine-4-carboxylate

Refernces