methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate

Base Information

• Chemical Name: methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate
• CAS No.: 439680-85-0
• Molecular Formula: C₂₀H₂₀Cl₃N₅O₈
• Molecular Weight: 564.766
• Mol file: 439680-85-0.mol

Synonyms:methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate

Chemical Property of methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate

There total 2 articles about methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.1%

triclopyr acid (55335-06-3) + methyl (S)-2-amino-6-(2,4-dinitrophenyl)aminohexanoate (10466-73-6) → methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate (439680-85-0)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1021/jf0114684

Reference yield:

Nε-2,4-dinitrophenyl-L-lysine hydrochloride (14401-10-6) → methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate (439680-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99.1 percent / SOCl₂ / 20 °C

2: 57.1 percent / HOBt; Et₃N; DCC / tetrahydrofuran / 4 h / 0 - 20 °C

With thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1021/jf0114684

Reference yield: 90.9%

methyl (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoate (439680-85-0) → (S)-2-[[[(3,5,6-trichloro-2-pyridyl)oxy]methylcarbonyl]amino]-6-(2,4-dinitrophenyl)aminohexanoic acid

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; for 2h;

DOI:10.1021/jf0114684

upstream raw materials:

triclopyr acid

methyl (S)-2-amino-6-(2,4-dinitrophenyl)aminohexanoate

Nε-2,4-dinitrophenyl-L-lysine hydrochloride

Refernces