5-(benzylidene)-1-methylhydantoin

Base Information

• Chemical Name: 5-(benzylidene)-1-methylhydantoin
• CAS No.: 31113-70-9
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.213
• Mol file: 31113-70-9.mol

Synonyms:5-(benzylidene)-1-methylhydantoin

Chemical Property of 5-(benzylidene)-1-methylhydantoin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-(benzylidene)-1-methylhydantoin

There total 6 articles about 5-(benzylidene)-1-methylhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzaldehyde (100-52-7) + diethyl 1-methyl-2,4-dioxoimidazolidine-5-phosphonate (109133-93-9) → 5-(benzylidene)-1-methylhydantoin (31113-70-9)

Guidance literature:

With sodium ethanolate; In ethanol; Ambient temperature;

DOI:10.1021/jo00024a036

Reference yield: 21.0%

1-methyldiazolidine-2,4-dione (616-04-6) + benzaldehyde (100-52-7) → 5-(benzylidene)-1-methylhydantoin (31113-70-9)

Guidance literature:

With pyridine; diethylamine; at 150 ℃; for 50h;

Reference yield: 10.0%

1,6-dimethylglycoluril (3720-98-7) + benzaldehyde (100-52-7) → 5-(benzylidene)-1-methylhydantoin (31113-70-9)

Guidance literature:

With trifluoroacetic acid; at 70 ℃; for 96h;

DOI:10.1021/jo100186q

upstream raw materials:

1-methyldiazolidine-2,4-dione

benzaldehyde

diethyl 1-methyl-2,4-dioxoimidazolidine-5-phosphonate

1,6-dimethylglycoluril

Downstream raw materials:

5-(p-chlorosulfonylbenzylidene)-1-methylhydantoin

Refernces

• 1、 Meanwell, Nicholas A.,Roth, Herbert R.,Smith, Edward C. R.,Wedding, Donald L.,Wright, J. J. Kim. "Diethyl 2,4-Dioxoimidazolidine-5-phosphonates: Horner-Wadsworth-Emmons Reagents for the Mild and Efficient Preparation of C-5 Unsaturated Hydantoin Derivatives". . p. 6897 - 6904. Retrieved 2007/10/02.