L-alpha-Methylleucine hy

Base Information

• Chemical Name: L-alpha-Methylleucine hy
• CAS No.: 88376-09-4
• Molecular Formula: C₇H₁₅NO₂*ClH
• Molecular Weight: 181.663
• Hs Code.: 2922499990
• Mol file: 88376-09-4.mol

Synonyms:L-alpha-Methylleucine hy

Chemical Property of L-alpha-Methylleucine hy

Chemical Property:

• PSA: 63.32000
• LogP: 2.33680

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Amino-2,4-dimethylpentan-1-olhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-alpha-Methylleucine hy

There total 2 articles about L-alpha-Methylleucine hy which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<(2S)-Methoxymethyl-1-pyrrolidinylmethyleneamino>-2,4-dimethylpentanoic acid, methyl ester (88224-34-4) → 2-Methylleucine, hydrochlorid (88376-09-4)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1) methanol, water, 18h, 25 deg C, 2) 60h, reflux;

Reference yield:

2-<(2S)-2-Methoxymethyl-1-pyrrolidinylmethyleneamino>-4-methylpentanoic acid, methyl ester (88224-31-1) → 2-Methylleucine, hydrochlorid (88376-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) diisopropylamine, n-butyllithium / 1) THF, hexane, -78 deg C, 1,5h

2: 3N HCl / 1) methanol, water, 18h, 25 deg C, 2) 60h, reflux

With hydrogenchloride; n-butyllithium; diisopropylamine;

upstream raw materials:

2-<(2S)-Methoxymethyl-1-pyrrolidinylmethyleneamino>-2,4-dimethylpentanoic acid, methyl ester

2-<(2S)-2-Methoxymethyl-1-pyrrolidinylmethyleneamino>-4-methylpentanoic acid, methyl ester

Refernces