3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester)

Base Information

• Chemical Name: 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester)
• CAS No.: 112113-88-9
• Molecular Formula: C₂₄H₃₀N₈O₅
• Molecular Weight: 510.553
• Mol file: 112113-88-9.mol

Synonyms:3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester)

Chemical Property of 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester)

There total 2 articles about 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

diethyl 2-azabutane-1,4-dicarboxylate (3783-61-7) + 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) → 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester) (112113-88-9)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 96h; Ambient temperature;

DOI:10.1021/jm00399a013

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) → 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester) (112113-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Et₃N / ethanol / 144 h

2: 53 percent / Et₃N, diethyl phosphorocyanidate / dimethylformamide / 96 h / Ambient temperature

With diethyl cyanophosphonate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00399a013

Reference yield: 76.0%

3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid bis(ethyl ester) (112113-88-9) → 3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid (112113-80-1)

Guidance literature:

With barium dihydroxide; In ethanol; Ambient temperature;

DOI:10.1021/jm00399a013

upstream raw materials:

diethyl 2-azabutane-1,4-dicarboxylate

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

ethyl acrylate

Downstream raw materials:

3-10methylpteroyl)-N-(carboxymethyl)amino>propanoic acid

Refernces