Multi-step reaction with 10 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 22 h / 90 - 140 °C
2.1: pyridine; potassium permanganate / water / 12 h / 85 °C
3.1: diphenyl phosphoryl azide; triethylamine / 18 h / 20 °C / Heating / reflux
4.1: trifluoroacetic acid / 1 h / 20 °C
5.1: pyridine / 2 h / 80 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
6.2: 15 h / 20 °C
7.1: trifluoroacetic anhydride / dichloromethane / 5 h / 20 °C
7.2: 15 h / 20 °C
8.1: pyridine / 3 h / 0 - 20 °C
8.2: 2 h / 60 °C
9.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C
9.2: 2 h / Heating / reflux
10.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
10.2: 72 h / 20 °C
With
pyridine; potassium permanganate; oxalyl dichloride; diphenyl phosphoryl azide; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride;
palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;