Benzenecarboximidic acid, N-methyl- (9CI)

Base Information

• Chemical Name: Benzenecarboximidic acid, N-methyl- (9CI)
• CAS No.: 88070-48-8
• Molecular Formula: C8H9 N O
• Molecular Weight: 135.166
• Hs Code.: 2924299090
• Mol file: 88070-48-8.mol

Synonyms:N-Methylbenzimidicacid

Chemical Property of Benzenecarboximidic acid, N-methyl- (9CI)

Chemical Property:

• Boiling Point: 254.9±23.0 °C(Predicted)
• PKA: 3.34±0.70(Predicted)
• PSA: 29.10000
• Density: 1.01±0.1 g/cm3(Predicted)
• LogP: 1.43710

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarboximidic acid, N-methyl- (9CI)

There total 289 articles about Benzenecarboximidic acid, N-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(benzoylamino)-1-phenylethanol (34119-82-9) → N-methylbenzamide (88070-48-8) + benzaldehyde (100-52-7)

Guidance literature:

With 2,4,6-trimethyl-pyridine; iron(III) chloride; 1,2-bis(2,4,6-triisopropylphenyl)disulfane; tetrabutyl-ammonium chloride; In 1,2-dichloro-ethane; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.1c03137

Reference yield: 76.0%

N-methyl-N-benzylbenzamide (61802-83-3) → N-methylbenzamide (88070-48-8) + benzaldehyde (100-52-7)

Guidance literature:

With N-Bromosuccinimide; In chloroform; at 20 ℃; for 18h; Further Variations:; Reagents; Solvents; Product distribution;

DOI:10.1055/s-2007-990795

Reference yield: 43.0%

methanol (67-56-1) + benzonitrile (100-47-0) → N-methylbenzamide (88070-48-8) + benzamide (55-21-0,27208-38-4) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With tris(2-diphenylphosphinoethyl)phosphine; water; caesium carbonate; cobalt(II) bromide; In m-xylene; at 140 ℃; for 24h; Reagent/catalyst;

DOI:10.1021/acscatal.9b03916

upstream raw materials:

1-methyl-4-nitrosobenzene

benzoic acid methylthiocarbamic acid-thioanhydride

N-methyl-α-phenylnitrone

acetic anhydride

Downstream raw materials:

N,N'-dimethylbenzoamidine

benzoic acid

N-Methyl-N-(trimethylsilyl)benzamide

N-Methyl-N-<3,3,3-trifluor(2-trifluormethyl)propionylbenzamid

Refernces

• 1、 -. "AMINE-BORANES AS BIFUNCTIONAL REAGENTS FOR DIRECT AMIDATION OF CARBOXYLIC ACIDS". Paragraph 0008-0009; 0063-0064. . Retrieved 2022/03/04.
• 2、 Qu, Erdong,Li, Shangzhang,Bai, Jin,Zheng, Yan,Li, Wanfang. "Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides". . p. 58 - 63. Retrieved 2021/12/27.