Carbonic acid, ethyl 2-hydroxyphenyl ester

Base Information

• Chemical Name: Carbonic acid, ethyl 2-hydroxyphenyl ester
• CAS No.: 32315-93-8
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.176
• DSSTox Substance ID: DTXSID101264832
• Mol file: 32315-93-8.mol

Synonyms:Carbonic acid, ethyl 2-hydroxyphenyl ester;32315-93-8;SCHEMBL3910917;DTXSID101264832

Chemical Property of Carbonic acid, ethyl 2-hydroxyphenyl ester

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)OC1=CC=CC=C1O

Technology Process of Carbonic acid, ethyl 2-hydroxyphenyl ester

There total 5 articles about Carbonic acid, ethyl 2-hydroxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-benzodioxol-2-one (2171-74-6) + ethanol (64-17-5) → ethyl (2-hydroxyphenyl) carbonate (32315-93-8) + Diethyl carbonate (105-58-8,76619-83-5)

Guidance literature:

With magnesium oxide; In neat (no solvent); at 80 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c6gc03466g

Reference yield:

ethyl phenyl carbonate (3878-46-4) → ethyl (2-hydroxyphenyl) carbonate (32315-93-8)

Guidance literature:

With dipotassium peroxodisulfate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; trifluoroacetic acid; trifluoroacetic anhydride; at 80 ℃; regioselective reaction; Sealed tube;

DOI:10.1002/adsc.201300999

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → ethyl (2-hydroxyphenyl) carbonate (32315-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / 24 h / 90 °C / Molecular sieve

2: magnesium oxide / neat (no solvent) / 1 h / 80 °C / Inert atmosphere

With sodium methylate; magnesium oxide; In neat (no solvent);

DOI:10.1039/c6gc03466g

upstream raw materials:

1,3-benzodioxol-2-one

ethanol

ethyl phenyl carbonate

benzene-1,2-diol

Downstream raw materials:

N-(ethoxycarbonyl)butylamine

1,3-benzodioxol-2-one

Refernces

• 1、 Yang, Xinglin,Sun, Yonghui,Chen, Zhang,Rao, Yu. "A general approach towards catechol and pyrogallol through ruthenium- and palladium-catalyzed C-H hydroxylation by weak coordination". supporting information. p. 1625 - 1630. Retrieved 2014/06/09.