N'-(1-phenylethylidene)benzohydrazide

Base Information

• Chemical Name: N'-(1-phenylethylidene)benzohydrazide
• CAS No.: 1219-41-6
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.289
• European Community (EC) Number: 658-170-2
• NSC Number: 404150
• DSSTox Substance ID: DTXSID00430525
• Mol file: 1219-41-6.mol

Synonyms:N'-(1-phenylethylidene)benzohydrazide;N'-[(1E)-1-phenylethylidene]benzohydrazide;1219-41-6;Acetophenonebenzoylhydrazone;(E)-N'-(1-phenylethylidene)benzohydrazide;14850-97-6;N-[(E)-1-phenylethylideneamino]benzamide;Benzoic acid, (1-phenylethylidene)hydrazide;DTXSID00430525;HMS1608B03;NSC404150;STK038691;AKOS000484974;NSC-404150;NCGC00322166-01;AB01317899-02

Chemical Property of N'-(1-phenylethylidene)benzohydrazide

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NNC(=O)C1=CC=CC=C1)C2=CC=CC=C2
• Isomeric SMILES: C/C(=N\NC(=O)C1=CC=CC=C1)/C2=CC=CC=C2

Technology Process of N'-(1-phenylethylidene)benzohydrazide

There total 16 articles about N'-(1-phenylethylidene)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzoic acid hydrazide (613-94-5) + phenylacetylene (536-74-3) → acetophenone N-benzoylhydrazone (14850-96-5,14850-97-6,1219-41-6)

Guidance literature:

With C₈₃H₆₄AuF₆N₃O₆S₂; In chlorobenzene; at 60 ℃; for 18h; Solvent; Reagent/catalyst; Catalytic behavior; Schlenk technique;

DOI:10.3762/BJOC.16.175

Reference yield: 92.0%

benzoic acid hydrazide (613-94-5) + acetophenone (98-86-2) → acetophenone N-benzoylhydrazone (14850-96-5,14850-97-6,1219-41-6)

Guidance literature:

With toluene-4-sulfonic acid; at 60 - 70 ℃; for 0.5h;

Reference yield: 57.0%

benzoic acid hydrazide (613-94-5) + acetophenone (98-86-2) → acetophenone N-benzoylhydrazone (14850-96-5,14850-97-6,1219-41-6) + N′-(1-phenylethyl)benzohydrazide (7654-03-7)

Guidance literature:

With borane pyridine; acetic acid; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1055/s-0033-1340484

upstream raw materials:

benzoic acid hydrazide

acetophenone

N-Benzoyl-N-trifylhydrazin

(1-bromoethyl)benzne

Downstream raw materials:

1-benzoyl-3-phenyl-5-(4-tolyl)pyrazole

4-phenyl-1,2,3-thiadiazole

benzoyl chloride

acetophenone

Refernces

• 1、 Ajayeoba, Temitope A.,Woods, Joseph O.,Ayeni, Ayowole O.,Ajayi, Tomilola J.,Akeem, Raji A.,Hosten, Eric C.,Akinyele, Olawale F.. "Synthesis, crystallographic, computational and molecular docking studies of new acetophenone-benzoylhydrazones". . . Retrieved 2021.
• 2、 Baell, Jonathan B.,Feng, Jiajun,He, Tiantong,Huang, Fei,Xie, Yuxing,Yu, Yang. "I2-Promoted [4 + 2] cycloaddition of: In situ generated azoalkenes with enaminones: Facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines". supporting information. p. 9483 - 9493. Retrieved 2020/12/15.
• 3、 Heidrich, Maximillian,Plenio, Herbert. "Efficient [(NHC)Au(NTf2)]-catalyzed hydrohydrazidation of terminal and internal alkynes". supporting information. p. 2080 - 2086. Retrieved 2020/09/18.