1-iodo-3-isopropylcyclohexane

Base Information

• Chemical Name: 1-iodo-3-isopropylcyclohexane
• CAS No.: 1285537-42-9
• Molecular Formula: C₉H₁₇I
• Molecular Weight: 252.138
• Mol file: 1285537-42-9.mol

Synonyms:1-iodo-3-isopropylcyclohexane

Chemical Property of 1-iodo-3-isopropylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-iodo-3-isopropylcyclohexane

There total 2 articles about 1-iodo-3-isopropylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-isopropyl-1-cyclohexanol (4534-77-4) → 1-iodo-3-isopropylcyclohexane (1285537-42-9)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane;

DOI:10.1021/acs.orglett.8b00784

Reference yield:

(1-methylethyl)-cyclohexane (696-29-7) → 1-iodo-3-isopropylcyclohexane (1285537-42-9)

Guidance literature:

With 1-methyl-1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201006879

Reference yield: 95.0%

1-iodo-3-isopropylcyclohexane (1285537-42-9) + ((triisopropylsilyl)ethynyl)zinc pivalate → triisopropyl(((cis)-3-isopropylcyclohexyl)ethynyl)silane

Guidance literature:

With trans-N,N,N′,N′-tetramethylcyclohexane-1,2-diamine; cobalt(II) chloride; In tetrahydrofuran; at 0 ℃; for 8h; diastereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00784

upstream raw materials:

(1-methylethyl)-cyclohexane

3-isopropyl-1-cyclohexanol

Refernces

• 1、 Thomas, Lucie,Lutter, Ferdinand H.,Hofmayer, Maximilian S.,Karaghiosoff, Konstantin,Knochel, Paul. "Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides". supporting information. p. 2441 - 2444. Retrieved 2018/04/27.