Technology Process of 3-[4,5-bis(ethoxycarbonylmethoxy)-2-nitrobenzyl]-1,7-dimethylxanthine
There total 5 articles about 3-[4,5-bis(ethoxycarbonylmethoxy)-2-nitrobenzyl]-1,7-dimethylxanthine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
paraxanthine;
With
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
4,5-bis(ethoxycarbonylmethoxy)-2-nitrobenzyl alcohol methanesulfonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
Further stages.;
DOI:10.1021/ja069361q
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 67 percent / NaBH4; AcOH / CH2Cl2; ethanol / 1.5 h / 0 - 5 °C
2.1: 90 percent / Et3N / CH2Cl2 / 3.5 h / 0 - 20 °C
3.1: K2CO3; n-Bu4NHSO4 / dimethylformamide / 1 h / 20 °C
3.2: 84 percent / dimethylformamide / 20 °C
With
sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; acetic acid; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja069361q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 90 percent / Et3N / CH2Cl2 / 3.5 h / 0 - 20 °C
2.1: K2CO3; n-Bu4NHSO4 / dimethylformamide / 1 h / 20 °C
2.2: 84 percent / dimethylformamide / 20 °C
With
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja069361q
