2-Chloro-5-(furan-2-yl)pyrazine

Base Information

• Chemical Name: 2-Chloro-5-(furan-2-yl)pyrazine
• CAS No.: 82619-63-4
• Molecular Formula: C8H5 Cl N2 O
• Molecular Weight: 180.593
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID30509233
• Wikidata: Q82366656
• Mol file: 82619-63-4.mol

Synonyms:82619-63-4;2-Chloro-5-(furan-2-yl)pyrazine;2-Chloro-5-(2-furanyl)pyrazine;2-Chloro-5-furan-2-yl-pyrazine;MFCD09033268;SCHEMBL2908651;DTXSID30509233;UNKRNSBYPINYEV-UHFFFAOYSA-N;AB3536;AKOS006330570;SB61108;AC-29795;AS-44719;SY029722;CS-0210472;A864374

Chemical Property of 2-Chloro-5-(furan-2-yl)pyrazine

Chemical Property:

• PSA: 38.92000
• LogP: 2.39000
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 180.0090405
• Heavy Atom Count: 12
• Complexity: 156

Purity/Quality:

99%min ^*data from raw suppliers

2-Chloro-5-(furan-2-yl)pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C2=CN=C(C=N2)Cl

Technology Process of 2-Chloro-5-(furan-2-yl)pyrazine

There total 2 articles about 2-Chloro-5-(furan-2-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-Hydroxy-5-(2'-furyl)pyrazine (82619-62-3) → 2-chloro-5-furan-2-yl-pyrazine (82619-63-4)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

Reference yield:

2-furylglyoxal monohydrate (20328-66-9) → 2-chloro-5-furan-2-yl-pyrazine (82619-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / aq.NaOH / methanol / 3 h / -30 - 10 °C

2: 52 percent / POCl₃ / 3 h / Heating

With sodium hydroxide; trichlorophosphate; In methanol;

Reference yield: 78.0%

2-chloro-5-furan-2-yl-pyrazine (82619-63-4) → 5-chloropyrazinoic acid (36070-80-1)

Guidance literature:

With potassium permanganate; Aliquat 336; In water; benzene; at 0 - 40 ℃; for 4h;

upstream raw materials:

2-Hydroxy-5-(2'-furyl)pyrazine

2-furylglyoxal monohydrate

Downstream raw materials:

5-chloropyrazinoic acid

5-hydroxypyrazinoic acid

methyl 5-chloropyrazine-2-carboxylate

methyl 5-methoxypyrazine-2-carboxylate

Refernces

• 1、 Sato, Nobuhiro,Arai, Shinji. "Studies on Pyrazines. 7 (1). The Synthesis of 5-Chloropyrazinecarboxylic Acid". . p. 407 - 408. Retrieved 2007/10/02.