trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate

Base Information

• Chemical Name: trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate
• CAS No.: 107271-35-2
• Molecular Formula: C₁₅H₂₄O₆
• Molecular Weight: 300.352
• Mol file: 107271-35-2.mol

Synonyms:trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate

Chemical Property of trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate

There total 3 articles about trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

trimethyl cyclohexane-1,3,5-tricarboxylate (52831-11-5) + dimethyl sulfate (77-78-1) → trimethyl-cis,cis-1,3,5-trimethyl-1,3,5-cyclohexane-tricarboxylate (79410-21-2) + trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate (107271-35-2)

Guidance literature:

With lithium diisopropyl amide; In diethyl ether; Yields of byproduct given; Ambient temperature;

DOI:10.1021/ja00242a029

Reference yield: 40.0%

1,3,5-cyclohexanetricarboxylic acid trimethyl ester (52831-11-5) + dimethyl sulfate (77-78-1) → trimethyl-cis,cis-1,3,5-trimethyl-1,3,5-cyclohexane-tricarboxylate (79410-21-2) + trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate (107271-35-2)

Guidance literature:

1,3,5-cyclohexanetricarboxylic acid trimethyl ester; With n-butyllithium; diisopropylamine; In diethyl ether; hexane; at 0 ℃; for 2h;

dimethyl sulfate; In diethyl ether; hexane; at 20 ℃;

DOI:10.1021/jo0206014

Reference yield: 12.0%

trimethyl cis,cis-cyclohexane-1,3,5-tricarboxylate (6998-83-0) + dimethyl sulfate (77-78-1) → trimethyl-cis,cis-1,3,5-trimethyl-1,3,5-cyclohexane-tricarboxylate (79410-21-2) + trimethyl cis,trans-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylate (107271-35-2)

Guidance literature:

trimethyl cis,cis-cyclohexane-1,3,5-tricarboxylate; With lithium diisopropyl amide; In diethyl ether; at 0 ℃; for 2h;

dimethyl sulfate; In diethyl ether; at 20 ℃; for 12h;

DOI:10.1002/jccs.200100032

upstream raw materials:

trimethyl cyclohexane-1,3,5-tricarboxylate

dimethyl sulfate

trimethyl cis,cis-cyclohexane-1,3,5-tricarboxylate

1,3,5-cyclohexanetricarboxylic acid trimethyl ester

Refernces

• 1、 Rebek,J.,Askew,B.,Killoran,M.. "-". . p. 2426. Retrieved 1987.