Thiazol-2-ol

Base Information

• Chemical Name: Thiazol-2-ol
• CAS No.: 82358-07-4
• Molecular Formula: C₃H₃NOS
• Molecular Weight: 101.129
• Hs Code.: 2934100090
• European Community (EC) Number: 832-172-5
• DSSTox Substance ID: DTXSID50459322
• Nikkaji Number: J149.680H
• Wikidata: Q63392576
• Mol file: 82358-07-4.mol

Synonyms:Thiazol-2-ol;2-HYDROXYTHIAZOLE;82358-07-4;2-THIAZOLOL;6039-97-0;3H-1,3-thiazol-2-one;Thiazol-2(3H)-one;hydroxythiazole;2-thiazolone;2,3-dihydro-1,3-thiazol-2-one;4-Thiazoline-2-one;1,3-thiazol-2-ol;2(3H)-Triazolone;2-(3H)-triazolone;2-Triazolone;SCHEMBL55245;2-Hydroxythiazole, AldrichCPR;SCHEMBL6122911;DTXSID50459322;MFCD02094166;AKOS008110156;AKOS015920160;AB10887;CS-W019762;GS-3983;BP-10800;FT-0647281;EN300-49410;A21570;J-509694;Q63392576;Z445210514

Chemical Property of Thiazol-2-ol

Chemical Property:

• Boiling Point: 251.0±23.0 °C(Predicted)
• PKA: 2.01±0.10(Predicted)
• PSA: 61.36000
• Density: 1.433±0.06 g/cm3(Predicted)
• LogP: 0.84870
• Storage Temp.: 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 100.99353489
• Heavy Atom Count: 6
• Complexity: 99

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxythiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=O)N1

Technology Process of Thiazol-2-ol

There total 4 articles about Thiazol-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-carboxaldehyde + N-{4-(4-fluorophenyl)-6-isopropyl-5-[(thiazol-2-ylsulfonyl)methyl]pyrimidin-2-yl}-N-methylmethanesulfonamide → N-(5-((E)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide + thiazol-2-ol (82358-07-4)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -60 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1338648

Reference yield:

(2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-carboxaldehyde + 2-({[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}sulfonyl)thiazole → (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one (1391833-12-7) + thiazol-2-ol (82358-07-4)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -60 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1338648

Reference yield:

thiazole-2-sulfonamide (113411-24-8) → thiazol-2-ol (82358-07-4)

Guidance literature:

With hydroxylamine; sodium hydroxide; In water; at 20 ℃; for 48h; pH=9 - 10;

DOI:10.1039/c2ob26929e

upstream raw materials:

2-bromo-1,3-thiazole

thiazole-2-sulfonamide

Refernces

• 1、 Fabris, Jan,?asar, Zdenko,Smilovi?, Ivana Gazi?,?rnugelj, Martin. "Highly stereoselective formal synthesis of rosuvastatin and pitavastatin through Julia-Kocienski olefination using the lactonized statin side-chain precursor". supporting information. p. 2333 - 2346. Retrieved 2014/12/09.