2-(4-fluorophenyl)-5-methylindolizine

Base Information

• Chemical Name: 2-(4-fluorophenyl)-5-methylindolizine
• CAS No.: 2992-75-8
• Molecular Formula: C₁₅H₁₂FN
• Molecular Weight: 225.265
• Mol file: 2992-75-8.mol

Synonyms:2-(4-fluorophenyl)-5-methylindolizine

Chemical Property of 2-(4-fluorophenyl)-5-methylindolizine

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-5-methylindolizine

There total 1 articles about 2-(4-fluorophenyl)-5-methylindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2,6-dimethylpyridine (108-48-5) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-fluorophenyl)-5-methylindolizine (2992-75-8)

Guidance literature:

2,6-dimethylpyridine; 2-bromo-4'-fluoroacetophenone; In acetone; at 90 ℃; for 72h; Inert atmosphere;

With potassium carbonate; In water; at 80 ℃; Inert atmosphere;

DOI:10.1002/anie.201302218

upstream raw materials:

2,6-dimethylpyridine

2-bromo-4'-fluoroacetophenone

Refernces

• 1、 Ortega, Nuria,Tang, Dan-Tam D.,Urban, Slawomir,Zhao, Dongbing,Glorius, Frank. "Ruthenium-NHC-Catalyzed asymmetric hydrogenation of indolizines: Access to indolizidine alkaloids". supporting information. p. 9500 - 9503. Retrieved 2013/09/23.