(±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran

Base Information

• Chemical Name: (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran
• CAS No.: 18539-44-1
• Molecular Formula: C₁₂H₁₅FO₂
• Molecular Weight: 210.248
• Mol file: 18539-44-1.mol

Synonyms:(±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran

Chemical Property of (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran

There total 4 articles about (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-fluorobenzylic alcohol (459-56-3) → (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran (18539-44-1)

Guidance literature:

With 1,4-diazabicyclo[2.2.2]octane tribromide supported on magnetic Fe₃O₄ nanoparticles; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1039/c7nj00479f

Reference yield: 89.0%

3,4-dihydro-2H-pyran (110-87-2) + (4-fluorobenzyloxy)trimethylsilane (14629-55-1) → (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran (18539-44-1)

Guidance literature:

With [K*18-crown-6]Br₃; water; In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1080/00304948.2019.1586430

Reference yield:

TETRAHYDROPYRANE (142-68-7) + 4-fluorobenzylic alcohol (459-56-3) → (±)-2-[(4-fluorobenzyl)oxy]tetrahydropyran (18539-44-1)

Guidance literature:

TETRAHYDROPYRANE; With bis(cyclopentadienyl)titanium dichloride; manganese; at 20 ℃; for 0.25h; Inert atmosphere;

4-fluorobenzylic alcohol; With Bromoform; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201500869

upstream raw materials:

3,4-dihydro-2H-pyran

4-fluorobenzylic alcohol

TETRAHYDROPYRANE

(4-fluorobenzyloxy)trimethylsilane

Downstream raw materials:

4-fluorobenzaldehyde

4-fluorobenzal chloride

4-fluorobenzylic alcohol

4-fluorobenzaldoxime

Refernces

• 1、 Chehardoli, Gholamabbas,Zolfigol, Mohammad Ali,Derakhshanpanah, Fateme. "Direct Conversion of TMS-ethers to THP-ethers Catalyzed by {[K.18-Crown-6]Br3}n". . p. 192 - 197. Retrieved 2019/04/27.
• 2、 Rostami, Amin,Pourshiani, Omid,Navasi, Yahya,Darvishi, Neda,Saadati, Shaghayegh. "Magnetic nanoparticle-supported DABCO tribromide: A versatile nanocatalyst for the synthesis of quinazolinones and benzimidazoles and protection/deprotection of hydroxyl groups". . p. 9033 - 9040. Retrieved 2017/08/29.