N,N'-benzylidenebis(benzyl carbamate)

Base Information

• Chemical Name: N,N'-benzylidenebis(benzyl carbamate)
• CAS No.: 169829-04-3
• Molecular Formula: C₂₃H₂₂N₂O₄
• Molecular Weight: 390.439
• Mol file: 169829-04-3.mol

Synonyms:N,N'-benzylidenebis(benzyl carbamate)

Chemical Property of N,N'-benzylidenebis(benzyl carbamate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-benzylidenebis(benzyl carbamate)

There total 1 articles about N,N'-benzylidenebis(benzyl carbamate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

O-benzyl carbamate (621-84-1) + benzaldehyde (100-52-7) → N,N'-benzylidenebis(benzyl carbamate) (169829-04-3)

Guidance literature:

With acetic anhydride; trifluoroacetic acid; at 20 ℃;

DOI:10.1134/S1070363211060041

Reference yield: 83.0%

N,N'-benzylidenebis(benzyl carbamate) (169829-04-3) + diethyl malonate (105-53-3) → 2-(benzyloxycarbonylamino-phenyl-methyl)-malonic acid diethyl ester

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

DOI:10.1002/anie.201300231

Reference yield: 82.0%

N-quinolin-8-yl-benzamide (33757-48-1) + N,N'-benzylidenebis(benzyl carbamate) (169829-04-3) → benzyl ((8-benzamidoquinolin-5-yl)(phenyl)methyl)carbamate

Guidance literature:

With silver hexafluoroantimonate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In 1,2-dichloro-ethane; at 65 ℃; for 18h; regioselective reaction;

DOI:10.1021/acs.orglett.6b02848

upstream raw materials:

O-benzyl carbamate

benzaldehyde

Downstream raw materials:

benzaldehyde

ammonia

methylammonium carbonate

toluene

Refernces

• 1、 Yurino, Taiga,Aota, Yusuke,Asakawa, Daisuke,Kano, Taichi,Maruoka, Keiji. "N-Boc-aminals as easily accessible precursors for less accessible N-Boc-imines: Facile synthesis of optically active propargylamine derivatives using Mannich-type reactions". . p. 3687 - 3700. Retrieved 2016/06/06.
• 2、 Kano, Taichi,Yurino, Taiga,Asakawa, Daisuke,Maruoka, Keiji. "Acid-catalyzed in situ generation of less accessible or unprecedented N-Boc imines from N-Boc aminals". supporting information. p. 5532 - 5534. Retrieved 2013/06/27.