Technology Process of diethyl 3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioate
There total 6 articles about diethyl 3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,3-diethyl 2-aminoglutarate; (3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine-8-carbaldehyde 1,1-dioxide;
With
acetic acid;
In
1,2-dichloro-ethane;
at 20 ℃;
for 1h;
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
With
potassium carbonate;
In
water; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C
1.2: Cooling with ice
2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
3.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 8.25 h / 20 - 80 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C
4.2: 1 h / Cooling with ice
5.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C
5.2: 20 °C
With
pyridine; hydrogenchloride; aluminum (III) chloride; diisobutylaluminium hydride; acetic acid; zinc;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
2.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 8.25 h / 20 - 80 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C
3.2: 1 h / Cooling with ice
4.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C
4.2: 20 °C
With
pyridine; diisobutylaluminium hydride; acetic acid; zinc;
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;