Technology Process of 11β,17-dihydroxy-21-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione
There total 1 articles about 11β,17-dihydroxy-21-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: NaI / acetone / 20 °C
2.1: NaI; HOAc / acetone / Heating
3.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C
4.1: 1.42 g / DMAP; pyridine / 25 h
5.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
5.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
6.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
7.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
8.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
With
pyridine; hydrogenchloride; dmap; 4 A molecular sieve; semicarbazide hydrochloride; trimethyl(benzyl)ammonium fluoride; acetic acid; sodium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetic acid; acetone;
1.1: Substitution / 2.1: Dehalogenation / 3.1: Dehydration / 4.1: silylation / 5.1: Metallation / 5.2: Methylation / 6.1: Addition / 7.1: Methylation / 8.1: Hydrolysis;
DOI:10.1021/jo981848x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaI / acetone / 20 °C
2: NaI; HOAc / acetone / Heating
With
acetic acid; sodium iodide;
In
acetone;
1: Substitution / 2: Dehalogenation;
DOI:10.1021/jo981848x
