2(3H)-Benzothiazolone,5-methoxy-,hydrazone(9CI)

Base Information

• Chemical Name: 2(3H)-Benzothiazolone,5-methoxy-,hydrazone(9CI)
• CAS No.: 80945-74-0
• Molecular Formula: C₈H₉N₃OS
• Molecular Weight: 195.245
• Mol file: 80945-74-0.mol

Synonyms:2(3H)-Benzothiazolone,5-methoxy-, hydrazone (9CI); Benzothiazole, 2-hydrazino-5-methoxy- (6CI);2-Hydrazino-5-methoxybenzothiazole

Chemical Property of 2(3H)-Benzothiazolone,5-methoxy-,hydrazone(9CI)

Chemical Property:

• PSA: 88.41000
• LogP: 2.36380

Purity/Quality:

99% ^*data from raw suppliers

2-Hydrazino-5-methoxy-1,3-benzothiazole 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(3H)-Benzothiazolone,5-methoxy-,hydrazone(9CI)

There total 4 articles about 2(3H)-Benzothiazolone,5-methoxy-,hydrazone(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxybenzo[d]thiazole-2-thiol (55690-60-3) → 2-hydrazinyl-5-methoxybenzo[d]thiazole (80945-74-0)

Guidance literature:

With potassium permanganate; potassium carbonate; hydrazine hydrate; Multistep reaction; 1) H₂O, 2) H₂O, heating, 8 h;

DOI:10.1002/ardp.19973300603

Reference yield:

2-amino-5-methoxybenzothiazole (54346-87-1) → 2-hydrazinyl-5-methoxybenzo[d]thiazole (80945-74-0)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; for 5h; Reflux;

DOI:10.1021/acs.jmedchem.8b01996 DOI:10.1021/acs.jmedchem.8b01996

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → 2-hydrazinyl-5-methoxybenzo[d]thiazole (80945-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 0 - 20 °C

2: hydrazine hydrate; hydrogenchloride / 5 h / Reflux

With hydrogenchloride; bromine; hydrazine hydrate; acetic acid;

DOI:10.1021/acs.jmedchem.8b01996 DOI:10.1021/acs.jmedchem.8b01996

upstream raw materials:

(4,6-dibromo-5-hydroxybenzofuran-2-yl)(4-phenoxyphenyl)methanone

5-methoxybenzo[d]thiazole-2-thiol

2-amino-5-methoxybenzothiazole

m-Anisidine

Refernces

• 1、 Chen, Ge,Niu, Chunyi,Yi, Jianhua,Sun, Lin,Cao, Hengyi,Fang, Yanjia,Jin, Taijie,Li, Ying,Lou, Chunli,Kang, Jingwu,Wei, Wanguo,Zhu, Jidong. "Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers". . p. 3107 - 3121. Retrieved 2019/04/01.