4-(METHOXYMETHYL)ANILINE

Base Information

• Chemical Name: 4-(METHOXYMETHYL)ANILINE
• CAS No.: 80936-82-9
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2922199090
• Mol file: 80936-82-9.mol

Synonyms:p-Toluidine,a-methoxy- (6CI); 4-Aminobenzylmethyl ether; 4-Methoxymethylaniline; 4-Methoxymethylphenylamine

Chemical Property of 4-(METHOXYMETHYL)ANILINE

Chemical Property:

• Vapor Pressure: 0.089mmHg at 25°C
• Refractive Index: 1.551
• Boiling Point: 224.917°C at 760 mmHg
• Flash Point: 93.539°C
• PSA: 35.25000
• Density: 1.048g/cm³
• LogP: 1.99640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4-(Methoxymethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(METHOXYMETHYL)ANILINE

There total 10 articles about 4-(METHOXYMETHYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methoxymethyl-4-nitrobenzene (1515-83-9) → 4-methoxymethyl-phenylamine (80936-82-9)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 1.5h; under 760.051 Torr; chemoselective reaction;

DOI:10.1016/j.tet.2015.10.037

Reference yield: 85.0%

1-bromo-4-methoxymethylbenzene (1515-88-4) → 4-methoxymethyl-phenylamine (80936-82-9)

Guidance literature:

With ammonium hydroxide; copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; acetylacetone; at 100 ℃; for 5h; Sealed tube;

Reference yield: 67.0%

para-methoxynitrobenzene (100-17-4) → 4-methoxymethyl-phenylamine (80936-82-9)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; Reflux;

DOI:10.1002/ejoc.201700705

upstream raw materials:

1-methoxymethyl-4-nitrobenzene

sodium methylate

p-toluidine (protonated)

methanol

Refernces

• 1、 Chen, Wenwen,Bao, Hailin,Wang, Dingsheng,Wang, Xinyan,Li, Yadong,Hu, Yuefei. "Chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers catalyzed by palladium-nickel bimetallic nanoparticles". . p. 9240 - 9244. Retrieved 2015/11/27.
• 2、 Baggerman, Jacob,Jagesar, Dhiredj C.,Vallee, Renaud A. L.,Hofkens, Johan,De Schryver, Frans C.,Schelhase, Franke,Voegtle, Fritz,Brouwer, Albert M.. "Fluorescent perylene diimide rotaxanes: Spectroscopic signatures of wheel-chromophore interactions". . p. 1291 - 1299. Retrieved 2007/10/03.