2,6-Naphthyridin-1-amine

Base Information

• Chemical Name: 2,6-Naphthyridin-1-amine
• CAS No.: 80935-81-5
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.164
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70512281
• Wikidata: Q82371458
• Mol file: 80935-81-5.mol

Synonyms:2,6-NAPHTHYRIDIN-1-AMINE;80935-81-5;[2,6]NAPHTHYRIDIN-1-YLAMINE;SCHEMBL246633;DTXSID70512281;KPMHXBFDZAJXLK-UHFFFAOYSA-N;MFCD11506145;AKOS006323551;AB64136;AT10483;CS-0244920;FT-0766767;EN300-2967078;A916802

Chemical Property of 2,6-Naphthyridin-1-amine

Chemical Property:

• Boiling Point: 363.672 °C at 760 mmHg
• Flash Point: 201.242 °C
• PSA: 51.80000
• Density: 1.293 g/cm³
• LogP: 1.79320
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 145.063997236
• Heavy Atom Count: 11
• Complexity: 137

Purity/Quality:

98%min ^*data from raw suppliers

2,6-naphthyridin-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C2=C1C=NC=C2)N

Technology Process of 2,6-Naphthyridin-1-amine

There total 11 articles about 2,6-Naphthyridin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-chloro-[2,6]naphthyridine (80935-78-0) → 1-amino-2,6-naphtyridine (80935-81-5)

Guidance literature:

With ammonia; In various solvent(s); at 175 ℃; for 6h;

Reference yield: 54.0%

2,6-naphthyridine (253-50-9) → 1-amino-2,6-naphtyridine (80935-81-5)

Guidance literature:

With ammonia; potassium amide; Ambient temperature;

Reference yield: 28.0%

1-bromo-2,6-naphthyridine (81044-15-7) → 1,5-diamino-2,6-naphthyridine (81044-13-5) + 1-amino-2,6-naphtyridine (80935-81-5)

Guidance literature:

With potassium amide; ferric nitrate; In ammonia; at -33 ℃; for 63h;

DOI:10.1021/jo00348a012

upstream raw materials:

1-bromo-2,6-naphthyridine

1-amino-1,2-dihydro-2,6-naphtyridimide

1-chloro-[2,6]naphthyridine

2,6-naphthyridine

Refernces

• 1、 Haak, Henk J. W. van den,Plas, Henk C. van der. "Occurrence of Even Telesubstitution in the Amination of Halogeno-2,6-naphthyridines". . p. 1673 - 1677. Retrieved 2007/10/02.