4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE

Base Information

• Chemical Name: 4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE
• CAS No.: 80745-07-9
• Molecular Formula: C10H13 Cl O3 S
• Molecular Weight: 248.73
• Hs Code.: 29093090
• Mol file: 80745-07-9.mol

Synonyms:4-Methoxy-2,3,6-trimethylbenzenesulfonylchloride; 4-Methoxy-2,3,6-trimethylphenylsulfonyl chloride

Chemical Property of 4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 2.05E-05mmHg at 25°C
• Melting Point: 57-61 °C
• Refractive Index: 1.521
• Boiling Point: 372.5°C at 760 mmHg
• Flash Point: 179.1°C
• PSA: 51.75000
• Density: 1.25g/cm³
• LogP: 3.62870
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE

There total 3 articles about 4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

2,3,5-trimethylanisole (20469-61-8) → 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; at -10 - -5 ℃;

Reference yield:

2,3,5-trimethylphenol (697-82-5) → 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 0 °C

1.2: 92 percent / tetrahydrofuran / 3 h / 0 °C

2.1: chlorosulfonic acid / CH₂Cl₂ / 1 h / 0 °C

With chlorosulfonic acid; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2006.12.122

Reference yield:

2,3,5-trimethylphenol (697-82-5) → 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99.8 percent / 60percent NaH in oil / dimethylsulfoxide / 10 h / Ambient temperature

2: 72.5 percent / chlorosulfonic acid / CH₂Cl₂ / -10 - -5 °C

With chlorosulfonic acid; sodium hydride; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

2,3,5-trimethylanisole

2,3,5-trimethylphenol

Downstream raw materials:

Mtr-Ile-OH

Z-Arg(Mtr)-OH*CHA

β-(O-benzyl)

methyl trans-4-[[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]cyclohexanecarboxylate

Refernces

• 1、 -. "Method for protecting amino group and restoring the same". . . Retrieved 2008/06/13.
• 2、 Fujino, Masahiko,Wakimasu, Mitsuhiro,Kitada, Chieko. "Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine". . p. 2825 - 2831. Retrieved 2007/10/02.