benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

• Chemical Name: benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
• CAS No.: 1020173-88-9
• Molecular Formula: C₃₈H₃₈FN₇O₅
• Molecular Weight: 691.762
• Mol file: 1020173-88-9.mol

Synonyms:benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property of benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Benzyl 6-(3-(tert-butyl)-5-(3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 7 articles about benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide (757251-39-1) + 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid (1020173-41-4) → benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1020173-88-9)

Guidance literature:

1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 20 ℃; for 1.5h;

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide; In 1,4-dioxane; at 95 ℃; for 4h;

Reference yield:

benzyl 6-(3-tert-butyl-5-(ethoxycarbonyl)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1020173-40-3) → benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1020173-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / ethanol; tetrahydrofuran / 3 h / 22 °C

1.2: pH 2 - 3

2.1: triethylamine; diphenyl phosphoryl azide / 1.5 h / 20 °C

2.2: 4 h / 95 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; triethylamine; In tetrahydrofuran; ethanol;

Reference yield:

benzyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1020174-05-3) → benzyl 6-(3-tert-butyl-5-(3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)ureido)-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1020173-88-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium periodate / water; tetrahydrofuran / 0.5 h / 25 °C

1.2: 2.5 h

2.1: pyridine; copper diacetate / dichloromethane / 40 h / 25 °C / Molecular sieve

3.1: lithium hydroxide monohydrate; water / ethanol; tetrahydrofuran / 3 h / 22 °C

3.2: pH 2 - 3

4.1: triethylamine; diphenyl phosphoryl azide / 1.5 h / 20 °C

4.2: 4 h / 95 °C

With pyridine; sodium periodate; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; copper diacetate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid

benzyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

(2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)boronic acid

Downstream raw materials:

1-(3-tert-butyl-1-(1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Refernces

• 1、 -. "KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES". Page/Page column 49. . Retrieved 2008/06/13.