(2-Iodoethyl)cyclohexane

Base Information

• Chemical Name: (2-Iodoethyl)cyclohexane
• CAS No.: 80203-35-6
• Molecular Formula: C8H15 I
• Molecular Weight: 238.112
• DSSTox Substance ID: DTXSID10513095
• Mol file: 80203-35-6.mol

Synonyms:(2-iodoethyl)cyclohexane;80203-35-6;2-iodoethylcyclohexane;2-CYCLOHEXYL-1-IODOETHANE;Cyclohexane, (2-iodoethyl)-;2-(iodoethyl)cyclohexane;(2-Iodo-ethyl)-cyclohexane;SCHEMBL1581527;DTXSID10513095;QQLSWNGYIUYOQV-UHFFFAOYSA-N;MFCD09039129;SY318966;CS-0244784;(2-Iodoethyl)cyclohexane - stabilized over Cu;EN300-2938474;A1-01524

Chemical Property of (2-Iodoethyl)cyclohexane

Chemical Property:

• PSA: 0.00000
• LogP: 3.39180
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 238.02185
• Heavy Atom Count: 9
• Complexity: 65

Purity/Quality:

97% ^*data from raw suppliers

(2-IODOETHYL)CYCLOHEXANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)CCI

Technology Process of (2-Iodoethyl)cyclohexane

There total 6 articles about (2-Iodoethyl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexanepropionic acid (701-97-3) → (2-iodoethyl)cyclohexane (80203-35-6)

Guidance literature:

With N-iodo-succinimide; iodine; In 1,2-dichloro-ethane; at 100 ℃; for 8h; Sealed tube; Darkness;

DOI:10.1002/ejoc.201501315

Reference yield: 92.0%

cyclohexylethan-1-ol (4442-79-9) → (2-iodoethyl)cyclohexane (80203-35-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/acs.orglett.9b01951

Reference yield: 80.0%

→ (2-iodoethyl)cyclohexane (80203-35-6)

Guidance literature:

upstream raw materials:

cyclohexylethan-1-ol

2-phenylethanol

1-bromo-2-cyclohexylethane

cyclohexanepropionic acid

Downstream raw materials:

dibromo-1,1 cyclohexyl-3 propane

vinylcyclohexane

ethyl-(2-cyclohexyl-ethyl)-ether

(2-cyclohexyl-ethyl)-triphenyl-phosphonium iodide

Refernces

• 1、 Geng, Hui-Qing,Wu, Xiao-Feng. "Copper-Catalyzed Alkoxycarbonylation of Alkyl Iodides for the Synthesis of Aliphatic Esters: Hydrogen Makes the Difference". supporting information. p. 8062 - 8066. Retrieved 2021/10/25.
• 2、 Liu, Qianyi,Hong, Junting,Sun, Beiqi,Bai, Guangcan,Li, Feng,Liu, Guoquan,Yang, Yang,Mo, Fanyang. "Transition-Metal-Free Borylation of Alkyl Iodides via a Radical Mechanism". supporting information. . Retrieved 2019/07/08.