C₂₆H₃₆O₅SSi

Base Information

• Chemical Name: C₂₆H₃₆O₅SSi
• CAS No.: 1281922-85-7
• Molecular Formula: C₂₆H₃₆O₅SSi
• Molecular Weight: 488.72
• Mol file: 1281922-85-7.mol

Synonyms:C₂₆H₃₆O₅SSi

Chemical Property of C₂₆H₃₆O₅SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₆O₅SSi

There total 3 articles about C₂₆H₃₆O₅SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one (303963-92-0) → C26H36O5SSi (1281922-85-7)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / 0 - 20 °C

3: dichloromethane; toluene / 48 h / 0 - 20 °C

4: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; cerium(III) chloride heptahydrate; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo2001897

Reference yield:

6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-one (1281922-74-4) → C26H36O5SSi (1281922-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / 0 - 20 °C

2: dichloromethane; toluene / 48 h / 0 - 20 °C

3: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; cerium(III) chloride heptahydrate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo2001897

Reference yield:

6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-ol (1281922-76-6) → C26H36O5SSi (1281922-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane; toluene / 48 h / 0 - 20 °C

2: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1021/jo2001897

upstream raw materials:

6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-one

6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-ol

(3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

Downstream raw materials:

(4-tert-butoxy-2,2-dioxo-tetrahydro-2-yl-6-cyclopenta[1,3,2]-dioxathiol-5-ylmethoxy)-tert-butyl-diphenyl-silane

MLN4924

C₄₈H₅₄N₄O₄SSi

{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

Refernces

• 1、 Lee, Hyuk Woo,Nam, Soo Kyung,Choi, Won Jun,Kim, Hea Ok,Jeong, Lak Shin. "Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme". . p. 3557 - 3561. Retrieved 2011/06/25.