C₂₆H₂₉F₂N₅O₃

Base Information

• Chemical Name: C₂₆H₂₉F₂N₅O₃
• CAS No.: 1422186-79-5
• Molecular Formula: C₂₆H₂₉F₂N₅O₃
• Molecular Weight: 497.545
• Mol file: 1422186-79-5.mol

Synonyms:C₂₆H₂₉F₂N₅O₃

Chemical Property of C₂₆H₂₉F₂N₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₉F₂N₅O₃

There total 6 articles about C₂₆H₂₉F₂N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C31H37F2N5O5 (1437787-43-3) → C26H29F2N5O3 (1422186-79-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1h;

Reference yield:

7-chloro-5-fluoroquinazolin-2-amine (1422188-40-6) → C26H29F2N5O3 (1422186-79-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: antimony(III) bromide / ethylene dibromide / 0.17 h / 20 °C / Inert atmosphere

1.2: 13 h / 50 °C

2.1: triethylamine / isopropyl alcohol / 2 h / 85 °C / Inert atmosphere

3.1: palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate / 1-methyl-pyrrolidin-2-one / 18 h / 150 °C / Inert atmosphere

3.2: 1 h / 50 °C

3.3: 0.03 h

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h

With hydrogenchloride; palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate; antimony(III) bromide; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; ethylene dibromide; isopropyl alcohol;

Reference yield:

4-chloro- 2,6-difluorobenzaldehyde (252004-45-8) → C26H29F2N5O3 (1422186-79-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N,N-dimethyl acetamide / 3 h / 140 °C / Inert atmosphere

2.1: antimony(III) bromide / ethylene dibromide / 0.17 h / 20 °C / Inert atmosphere

2.2: 13 h / 50 °C

3.1: triethylamine / isopropyl alcohol / 2 h / 85 °C / Inert atmosphere

4.1: palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate / 1-methyl-pyrrolidin-2-one / 18 h / 150 °C / Inert atmosphere

4.2: 1 h / 50 °C

4.3: 0.03 h

5.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h

With hydrogenchloride; palladium(II) trifluoroacetate; dicyclohexyl(3-dicyclohexylphosphaniumylpropyl)phosphonium ditetrafluoroborate; antimony(III) bromide; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; ethylene dibromide; isopropyl alcohol;

upstream raw materials:

4-chloro- 2,6-difluorobenzaldehyde

7-chloro-5-fluoroquinazolin-2-amine

7-chloro-5-fluoroquinazolin-2-amine

C₁₃H₁₃ClFN₃O

Refernces