Technology Process of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
There total 6 articles about 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine; 2-(cyclohexylmethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride hydrochloride;
In
dichloromethane;
at 5 - 25 ℃;
for 4h;
With
potassium carbonate;
In
water; ethyl acetate;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ethanol; water / 0.5 h / 65 °C / Inert atmosphere; Industry scale
2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.75 h
2.2: 1.17 h
3.1: dichloromethane / 4 h / 5 - 25 °C
3.2: 0.5 h
With
hydrogenchloride;
In
ethanol; dichloromethane; tert-butyl methyl ether; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tris(acetoxy)borohydride / tert-butyl methyl ether / 2.5 h / 8.8 - 21.1 °C / Industry scale
1.2: 0.5 h / 20 °C / Industry scale
1.3: 20 °C / Industry scale
2.1: chlorosulfonic acid / dichloromethane / -1.8 - 35 °C / Industry scale
3.1: dichloromethane / 4 h / 5 - 25 °C
3.2: 0.5 h
With
chlorosulfonic acid; sodium tris(acetoxy)borohydride;
In
dichloromethane; tert-butyl methyl ether;