(3S,4S)-TETRAHYDROFURAN-3,4-DIOL

Base Information

• Chemical Name: (3S,4S)-TETRAHYDROFURAN-3,4-DIOL
• CAS No.: 84709-85-3
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Hs Code.: 2932190090
• Mol file: 84709-85-3.mol

Synonyms:3,4-Furandiol,tetrahydro-, (3S-trans)-;(S,S)-Tetrahydrofuran-3,4-diol;1,4-Anhydro-L-threitol;

Chemical Property of (3S,4S)-TETRAHYDROFURAN-3,4-DIOL

Chemical Property:

• Melting Point: 63-64 °C
• Boiling Point: 221.8 °C at 760 mmHg
• PKA: 13.66±0.40(Predicted)
• Flash Point: 104 °C
• PSA: 49.69000
• Density: 1.411 g/cm³
• LogP: -1.26160
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1,4-Anhydro-L-threitol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3S,4S)-TETRAHYDROFURAN-3,4-DIOL is a tetrahydrofuran derivative used in the preparation of hyperbranched carbohydrate polymers via ring-opening reaction. Labelled analogue of 1,4-Anhydro-L-threitol, a tetrahydrofuran derivative used in the preparation of hyperbranched carbohydrate polymers via ring-opening reaction.

Technology Process of (3S,4S)-TETRAHYDROFURAN-3,4-DIOL

There total 2 articles about (3S,4S)-TETRAHYDROFURAN-3,4-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4-butanetetrol (2319-57-5,2418-52-2,6968-16-7,7493-90-5,7541-59-5,10030-58-7,188346-77-2,149-32-6) → (3S,4S)-tetrahydro-3,4-furandiol (84709-85-3)

Guidance literature:

In water; at 249.84 ℃; Temperature; Kinetics; Inert atmosphere;

DOI:10.1039/c6cp06831f

Reference yield:

→ (3R,4R)-3,4-dihydroxytetrahydrofuran (473-85-8) + (3S,4S)-tetrahydro-3,4-furandiol (84709-85-3)

Guidance literature:

Reference yield: 82.0%

methanesulfonyl chloride (124-63-0) + (3S,4S)-tetrahydro-3,4-furandiol (84709-85-3) → (3S,4S)-(+)-3,4-Bis(methylsulfonyloxy)tetrahydrofuran (144788-32-9,59676-26-5)

Guidance literature:

With pyridine; In dichloromethane; 1.) -30 deg C, 8 h, 2.) r.t., 12 h;

DOI:10.1055/s-1992-26275

upstream raw materials:

1,2,3,4-butanetetrol

Downstream raw materials:

tetraphenyl (3S,4S)-tetrahydrofuran-3,4-diyl diphosphite

(3S,4S)-(+)-3,4-Bis(methylsulfonyloxy)tetrahydrofuran

(3S,4S)-tetrahydrofuran-3,5-diyl bis(diphenylphosphinite)

C₁₈H₂₀O₇S₂

Refernces

• 1、 -. "Quinazoline compound and anti-tumor agent containing said compound as an active ingredient". . . Retrieved 2008/06/13.