2-iodophenyl hydroxamic acid

Base Information

• Chemical Name: 2-iodophenyl hydroxamic acid
• CAS No.: 79271-23-1
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.035
• Mol file: 79271-23-1.mol

Synonyms:2-iodophenyl hydroxamic acid

Chemical Property of 2-iodophenyl hydroxamic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-iodophenyl hydroxamic acid

There total 4 articles about 2-iodophenyl hydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Iodobenzoyl chloride (609-67-6) → 2-iodophenyl hydroxamic acid (79271-23-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 0.0833333h;

Reference yield: 92.0%

o-iodo-methyl-benzoic acid (610-97-9) → 2-iodophenyl hydroxamic acid (79271-23-1)

Guidance literature:

With hydroxylamine hydrochloride; In dimethyl sulfoxide; at 25 ℃; Alkaline conditions;

DOI:10.1016/j.tetlet.2016.10.037

Reference yield: 71.0%

→ 2-iodophenyl hydroxamic acid (79271-23-1)

Guidance literature:

With potassium hydroxide; hydroxylamine; In methanol; at 20 ℃; for 12h; pH=10;

DOI:10.1039/b822806j

upstream raw materials:

2-Iodobenzoyl chloride

2-Iodobenzoic acid

o-iodo-methyl-benzoic acid

Downstream raw materials:

2-iodophenylamine

2-(2-iodophenyl)-4H-benzo[d][1,3]oxazin-4-one

N-formyl-2-iodoaniline

Refernces

• 1、 Jia, Mengmeng,Zhang, Heng,Lin, Yongjia,Chen, Dimei,Chen, Yanmei,Xia, Yuanzhi. "Consecutive Lossen rearrangement/transamidation reaction of hydroxamic acids under catalyst- and additive-free conditions". . p. 3615 - 3624. Retrieved 2018/05/26.
• 2、 Ohtsuka, Naoya,Okuno, Moriaki,Hoshino, Yujiro,Honda, Kiyoshi. "A base-mediated self-propagative Lossen rearrangement of hydroxamic acids for the efficient and facile synthesis of aromatic and aliphatic primary amines". supporting information. p. 9046 - 9054. Retrieved 2016/10/05.